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A conventional derailleur moves diagonally to move the chain to larger cogs. Eagle derailleurs move horizontally and the change in chain tension moves the upper pulley to larger cogs. If you use an Eagle derailleur on a 2x, when you shift down in the front, the upper pulley will move and contact the cogs.
It is the same for Shimano. Shimano has 2x 12 speed mountain derailleurs, but the max cog is 45. If you really want to do this check out this thread at MTBR, I think there are some ways to do it.
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