Two of us riding bikes with drop bars with max tire width of 700 x 45 are going to ride about 1,000 miles of GDMBR as a test ride for the whole thing to learn what we need. Bikes probably not ideal but we're committed to running what you got - as opposed to getting new bikes or 650b wheelsets.
Neither of us are clydesdales but a few of the days with so few or no options for water (Atlantic City and Rawlings or between Salida and Saguache) we'll be loaded with water, food besides the other requisite gear.
Tire recs helpful - also interested if folks would run Cush Core or some other liner with them.
My friend and I have done a few long pointlessly hilly tours together but have no experience with this particular route.